Lasix is a pharmacological agent that specifically acts on the kidneys, accelerates the excretion of urine from the body by inhibiting the reabsorption of electrolytes in the tubules and the release of an appropriate amount of fluid. It is used for cardiovascular pathologies, most often — for arterial hypertension to relieve the bloodstream.
The drug is produced by the French pharmaceutical company Sanofi, founded in 1973, and currently has great popularity all over the world. The company has several modern and highly equipped factories, produces more than a hundred medicinal products, including vaccines, innovative drugs and veterinary products.
The main groups of drugs supplied to the pharmacological market are hormonal drugs, drugs for the treatment of diseases of the cardiovascular, respiratory, musculoskeletal, urinary systems, vaccines as well as serums.
Lasix belongs to the class of diuretic drugs. Diuretics increase the excretion of urine from the body and reduce its content in cavities, vessels, and tissues. The mechanism of action is associated with the effect on the renal apparatus, in which the reverse absorption of sodium ions is inhibited.
This leads to the fact that the absorption of water slows down, so it freely passes through the renal tubules and is excreted in the urine. Filtration processes in the kidneys are enhanced at the same time. There are loop diuretics that act at the level of the loop of the renal apparatus.
Diuretics are also used to normalize the pressure of the fundus in complex therapy, to reduce intracranial pressure, to improve the condition of a patient poisoned with toxic substances, to prevent epilepsy attacks.
Indications for use
Indications in complex therapy are as follows:
- Edema of various origins associated with diseases of the cardiovascular system, kidneys, pregnancy, intoxication.
- Edema of the brain and spinal cord, intracranial hypertension, pulmonary edema as emergency methods of therapy.
- High blood pressure.
- Kidney function insufficency
Among the side effects can be noted:
- Dryness and discomfort in the mouth, dryness of the mucous membranes, thirst.
- Dyspeptic disorders, nausea, vomiting, unspecified abdominal pain, constipation, frequent loose stools.
- Inflammation of the pancreas.
- Hypovolemia, dehydration, a decrease in the level of potassium in the blood below normal, sodium, chlorine, calcium and related disorders, an increase in the concentration of uric acid in the blood.
- Inflammation of the skin and its appendages, hearing and vision disorders, a feeling of crawling goosebumps on the skin, tingling, numbness, dizziness of a systemic and non-systemic nature, muscle weakness.
- Delayed urinary excretion in patients with a benign prostate tumor.
- An increase in the level of cholesterol and “harmful” lipoproteins, as well as triglycerides.
- Reduction of glucose tolerance based on a laboratory test.
- Acute inflammation of the pancreas.
If an overdose is suspected, it is necessary to consult a doctor, since in case of an overdose, certain therapeutic measures may be required.
The clinical picture of acute or chronic overdose of the drug depends mainly on the degree and consequences of loss of fluid and electrolytes; overdose can be manifested by hypovolemia, dehydration, hemoconcentration, cardiac arrhythmias and conduction disorders (including atrioventricular blockade and ventricular fibrillation). Symptoms of these disorders are arterial hypotension (up to the development of shock), acute renal failure, thrombosis, delirium, sluggish paralysis, apathy and confusion.
There is no specific antidote. If a little time has passed after oral administration, then to reduce the absorption of furosemide from the gastrointestinal tract, you should try to induce vomiting or perform gastric lavage, and then take activated charcoal inside.
The treatment is aimed at correcting clinically significant disorders of the water-electrolyte and acid-base state under the control of serum concentrations of electrolytes, indicators of the acid-base state, hematocrit, as well as at preventing or treating possible serious complications developing against the background of these disorders.