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Clomid is a drug for the treatment of infertility, used to diagnose disorders of the gonadotropic function of the pituitary gland. The active substance of the drug is clomiphene. Clomiphene belongs to antiestrogenic agents and selectively blocks the receptor binding of estradiol in the ovaries and hypothalamus.

This leads to the suppression of the negative feedback, stimulates ovulation and the production of gonadotropins. Clomid has a moderate estrogenic effect when using low doses of the drug, increases the secretion of gonadotropins, stimulates ovulation. When using high doses, the drug shows an anti-estrogenic effect as well as inhibits the production of gonadotropins.

Application

Clomid is used to treat infertility in women and men in case of:

  • Anovulatory infertility
  • Dysgonadotropic form of amenorrhea
  • Dysfunctional metrorrhagia
  • A pituitary tumor that developed against this background, galactorrhea
  • Stein-Leventhal syndrome
  • Chiari-Frommel Syndrome
  • Oligospermia
  • Androgen deficiency

As a treatment for infertility and ovulation stimulation, Clomid is prescribed before bedtime from the fifth day of the menstrual cycle. Take the drug Clomid for five days. If there is no menstrual cycle, then the drug is applied without taking into account the menstrual cycle.

If there are no changes during the month and ovulation has not occurred, the doctor increases the dose of the drug as well as the number of days of the course of treatment. During the course of treatment, constant monitoring of the effect of the drug is carried out. This means assessing how the process of ovulation is going on – the basal temperature is measured, the change in the level of luteinizing hormone is checked; when calculating the average phase of luteinization or in women with amenorrhea during menstruation, the growth of serum progesterone is determined.

If it is established that ovulation has occurred, but pregnancy has not – the doctor prescribes another course of treatment with the same doses of Clomid. If menstruation did not occur, and ovulation was on all signs, then you should undergo a pregnancy examination before the next course of treatment.

The use of the drug for men is indicated for several months under strict systematic control of the spermogram. Clomid has proven to be effective for stimulating the production of gonadotropins, but it does not show properties in gynecomastia in breast tissues.

Contraindications

The use of Clomid is not recommended for renal or hepatic insufficiency, hypersensitivity to the drug, ovarian cyst, neoplasms in the reproductive organs, endometriosis, pregnancy, tumors of the pituitary gland or its hypofunction, an unclear etiology of metrorrhagia, hyperprolactinemia with ovarian insufficiency on its background.

Side effects of the drug

The drug Clomid can cause drowsiness, dizziness, depression, insomnia, increased excitability, and headache. When taking Clomid, nausea, diarrhea, vomiting, and gastralgia may occur. Allergic manifestations rarely appear. If so, allergic dermatitis and vasomotor disorder are possible. When treated with the drug, it is possible to increase body weight, soreness in the mammary glands, decreased visual acuity, abdominal pain, menorrhagia, an increase in the size of the ovary and other disorders. When using Clomid, there may be an increase in the risk of blood clots.

When treated with the drug, a multiple pregnancy may develop. It should be borne in mind that the effectiveness of the drug increases with a normal level of endogenous estrogens; with a low level of estrogens, it is ineffective, and with a lack of pituitary gonadotropins, it is practically not effective. During the treatment of female infertility, there should be monitoring of the condition of the ovaries and their functionality.

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Clomid in the right combination with other drugs helps to restore muscles and maintain relief, endurance and strength indicators. It also participates in the correction of biochemical processes, the restoration of the hormonal background, the normalization of metabolism and the preservation of energy balance.